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and significant improvements in ALT, AST, bilirubin, bile acids, cytokeratin-18, insulin, estimated glomerular filtration rate, ELF score, and hepatic stiffness by transient elastography (p 0.05 in all cases)

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Higher Doses: Some individuals, under professional supervision, may explore doses up to 20 mg or more, but this increases the risk of unknown side effects

Subsequent debate regarding assay specificity, circulating concentrations, and translational relevance led to skepticism regarding irisins role in humans

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