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The HTLV-1 neurological complex

In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 2002)

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Over repeated relapses, oligodendrocytes are lost and axons degenerate, leading to irreversible disability

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