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Accumulation of krebs cycle intermediates and over-expression of hif1alpha in tumours which result from germline fh and sdh mutations

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Prolonged UV exposure can induce matrix metalloproteinase-2 (MMP-2) and MMP-9 activation in basement membrane which can lead to collagen types 4 and 6 degradation and accumulation of more elastic fibers in melasma patients (Inomata et al., 2003)

Spot-checking one vial per run is industry standard