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In colon cancer cells (HT-29 and SW480 cells), genetic knockout of IGF-1R or the use of the IGF-1R inhibitor NVP-ADW742 enhanced the killing effect of radiation on cancer cells, confirming that depletion of IGF-1R improves radiosensitivity to colon cancer therapy (145,146)

In fibromyalgia, neurons in the spinal cord and brain become hyperexcitable, responding to normal sensory input as if it were painful

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Discussing lifestyle factors, including alcohol intake, diet, and physical activity levels

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