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Zhang Z, Chen Y, Chen Y, Jeter M, Hofstetter WL, Ajani J, Swisher SG , Chang JY, Allen PK, Cox JD, Komaki R, Liao ZX

Currently, long-acting GLP-1 agonists dominate the GLP-1 market, and this trend is expected to persist in the coming years

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Glucagon receptor agonism works predominantly in the liver: it drives glycogenolysis (glycogen breakdown), fatty acid oxidation, suppressed lipogenesis (creation of triglycerides), and gluconeogenesis (making new sugar)