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A comprehensive strategy for decreasing vascular risk should incorporate dietary and lifestyle changes along with thorough cholesterol and lipoprotein testing and strategic nutrient and pharmaceutical interventions

Diabetologia 42:102106 [DOI] [PubMed] [Google Scholar] Regoli F, Winston GW (1999) Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals

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However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC