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[7] [8] GLP-1 receptor agonists (such as semaglutide, liraglutide, and dulaglutide) are now widely prescribed medications for type 2 diabetes and obesity management, approved by the MHRA and recommended in NICE guidelines (NG28 for type 2 diabetes

These agents enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

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J Clin Invest 117:29933006

Whether those concentrations are high enough to reliably activate receptors at the ultra-low end (0.25-0.5 mg) is genuinely uncertain

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