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Studies of the microbiome indicate a loss of butyrate-producing bacteria and altered microbial metabolites

This formed the basis for Black's development of the first beta-blocker, propranolol, at Imperial Chemical Industries, a chemical conglomerate with pharmaceutical laboratories in Cheshire that he joined in 1958 and stayed with until 1964 when he moved to Smith Kline and French, an American pharmaceutical company with laboratories in Hertfordshire, South East England

The quantification of hepatic lipids revealed that HZRG treatment also decreased liver TG content, which was consistent with the pathological change (Figure 2D)

8. Clinical Testing

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