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Although this dose is more than three times higher than the dose given to adult diabetics via subcutaneous administration, it reflects what we have previously shown in a mouse model of hypoxic-ischemic encephalopathy, where a higher dose of 0.5 g/g is required for therapeutic efficacy in the brain 9

15 mL dose line)

Hlscher, 2020

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Metopimazine is a dopamine D2 receptor antagonist that exerts its antiemetic effects via the chemoreceptor trigger zone, which mediates nausea and vomiting through peripheral receptors