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Retatrutide, because it adds glucagon receptor activation, may cause additional metabolic effects that neither semaglutide nor tirzepatide produce, including greater fat oxidation and potentially different hunger pattern changes

You want to avoid extremes

while serum values of B12 seem to rise, none of the B12 is available for the body to use

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There are concerns about adherence to oral treatment, for example, if the person: Is older, is or has recently been in hospital and has either multimorbidity or frailty