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Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction

What may distinguish certain peptide therapeutics is the degree of physiological mimicry involved, which can make it harder to predict adaptive homeostatic responses in advance

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In rodent and limited human research, the reported effects include better attention, lower baseline anxiety, and improved sleep quality

Zhang J, Xue C, Zhu T, Vivekanandan A, Pennathur S, Ma ZA, Chen YE (2013) A tripeptide Diapin effectively lowers blood glucose levels in male type 2 diabetes mice by increasing blood levels of insulin and GLP-1

These observations correlate with previous data indicating that few orally administered drugs and clinical candidates exceed MWs of 1000 Da