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Riboflavin deficiency-implications for general human health and inborn errors of metabolism

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290 In addition, p53 plays a critical role in regulating CVDs, including myocardial ischemia/reperfusion injury, heart failure, pressure overload- and diabetes-induced maladaptive remodeling and atherosclerosis

In normal physiology, ammonium derived from deamination is transported as glutamine or alanine to hepatocyte mitochondria, where it undergoes enzymatic conversion to urea via the urea cycle (Details in Table 1 )

It has been found that mitochondrial damage or dysfunction can contribute to ROS accumulation and cell death, leading to dysregulation of energy metabolism and cellular dysfunction, which subsequently induces inflammation and OS