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doi: 10.1097/wnr.0000000000000071 52 ZhangWXieYWangTBiJLiHZhangLiQet al

Unlike earlier GHRPs, Ipamorelin is often researched for its receptor specificity and minimized interaction with cortisol or prolactin pathways in controlled laboratory settings

This specific property has become the focus of numerous research strategies, such as the development of senolytic agents like FOXO4-DRI, which selectively disrupt the FOXO4p53 interaction, thereby enabling the targeted elimination of dysfunctional cells

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In addition, symptom relief following abstinence helps define CHS, according to the Rome IV criteria (Table 1)

This creates an important clinical reality