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2016;34(15_suppl):108

These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +

Three key modifications optimize its pharmacokinetics: Aib substitution at position 2 resists DPP-4 cleavage C18 fatty diacid via a hydrophilic linker at Lys26 enables strong, non-covalent albumin binding Arg substitution at position 34 prevents fatty acid binding at the wrong site These modifications produce a half-life of approximately 165 hours (7 days), enabling true once-weekly pharmacokinetics without microsphere encapsulation, plus a daily oral formulation (Rybelsus) using the SNAC absorption enhancer

However, GLP-1s can affect postpartum people differently than the general population, and medication timing and postpartum physiology are important to consider

Again, this is a very personal decision - one that should be made in conjunction with your doctor

Es importante estar atento a cualquier reaccin adversa al comenzar la suplementacin