these components are well documented to produce oxidative damage, proteolytic cleavage of extracellular and cellular proteins, and direct cytotoxicity in other tissue contexts [56]
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Each KLOW component supports different phases of this cascade
Together, these studies identified a histone acetylation pathway that is promoted by KG production and suggest demethylation reactions are dispensable for the observed HR-proficiency and corresponding resistance to DNA damaging agents
Both our sensitivity analyses and the application of alternative filtering thresholds yielded consistent results, supporting the stability of our findings