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GLP-1 receptor agonists are reasonable alternatives to SGLT-2 inhibitors in patients with similar risk profiles because this drug class also improves mortality, although to a lesser extent

Author contributions AB, NK, AK, RK, SR, JO, KS, CS, and SS contributed to the techniques and generated data

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Tirzepatide trials (SURPASS series) showed similar safety profiles for mood-related adverse events

A pivotal 2007 study published in the Journal of Physiology and Pharmacology examined rats with experimentally induced esophagitis and sphincter failure