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Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer

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It is also independently associated with abnormal lipid metabolism as well as an increased risk of cardiovascular and cerebrovascular disease compared to E3 and E2 alleles (Belloy et al., 2019

Understanding this timeline helps set realistic expectations and determine whether observed changes represent expected gradual decline or concerning rapid reversal suggesting dependency or underlying issues