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In the LOOK-AHEAD study, 5145 participants aged 4576 years (mean BMI 36 kg/m 2 ) with T2D were randomized to either calorie restriction or diabetes support and education intervention (controls) [33]

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Differences in gene expression and cytokine release profiles highlight the heterogeneity of distinct subsets of adipose tissue-derived stem cells in the subcutaneous and visceral adipose tissue in humans