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However, potential adverse drug effect, fragmented healthcare system and heavy economic burden all pose great challenges to patients long-term compliance, which largely weakens the effectiveness of drug therapy

Determination was conducted in a Nunc U-bottom 96-well plate (Thermo Scientific, Waltham, MA, USA) on a Varioskan LUX Multimode Microplate Reader (Thermo Scientific, Waltham, MA, USA)

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This includes HPLC (High-Performance Liquid Chromatography) and Mass Spectrometry to verify identity, purity, and stability