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As previously noted, a larger proportion of hospitals would be impacted by the blanket 1-star reduction (Stage 2 proposed methodological change) compared to the targeted 4-star cap (Stage 1 proposed methodological change)

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Specificity for target tissues can be increased through surface modification such as conjugation of ligands, antibodies or peptides, which can enhance efficacy while reducing toxicity [29]

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The side effect picture changes above 500 mcg per day and in people on SSRIs or SNRIs