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(a) In mammals without excess adiposity, leptin binds normally to LEPR, initiating the phosphorylation cascade of JAK2 and tyrosine residues within the intracellular domain of LEPR (Y985, Y1077, and Y1138)

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It stays active in the bloodstream, reaching tissues throughout the body and exerting its effects for over a full day after each injection

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Which Is More Effective for Weight Management

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