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Incretin-based therapies in type 2 diabetes mellitus

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

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Incretins are gut-derived hormones that are secreted after eating and help stimulate insulin secretion in response to glucose

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Inadequate protein intake, reduced physical activity, and dehydration may also contribute