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Impaired mitochondrial fusion and enhanced mitochondrial fission have been reported in mice with Mfn2 gene knockout, which was accompanied by metabolic disorders such as glucose intolerance, enhanced hepatic gluconeogenesis, and leptin resistance (66, 103)

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Post-inflammatory hyperpigmentation (PIH) is one of the most common disorders of acquired hyperpigmentation

Indeed, Kang reported that human volunteers who ingested supratherapeutic doses of APAP (80 mg/kg) excreted dramatically lower amounts of APAP oxidative (CYP450) metabolites in urine when treated with fomepizole ( Figure 21 )

33 , e2437 (2023)

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet