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Summary PD is commonly associated with fibrotic disorders (e.g., Dupuytrens contracture), cardiovascular diseases (e.g., hypertension, atherosclerosis), metabolic conditions (e.g., diabetes, obesity), and hormonal imbalances (e.g., low testosterone)

Tesamorelin functions as a stabilized GHRH analog, while Ipamorelin functions as a selective ghrelin receptor agonist

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Both human [87] and mouse studies [88, 89] demonstrated that a Plin1 deficiency enhanced ectopic fat distribution and impaired insulin sensitivity

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Animal and cell work indicate that peptides may impact growth hormone signaling and pathways related to it