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and its bioactive metabolites, with a specific focus on their mechanistic actions and therapeutic potential in the context of skin diseases
We acknowledge the limitations of using metabolite concentrations as clinical biomarkers
The bound protein was eluted with a linear gradient of PBS buffer supplemented with 1 M KCl buffer and then modified by reductive methylation with formaldehyde and Dimethylamineborane complex
61,62,63 CDO is highly regulated at the level of protein turnover, as oxidative degradation of cysteine by CDO is highly inducible, 64 and high cysteine levels inhibit CDO ubiquitinylation and reduce its proteasomal degradation
This antioxidant rids the body of free radicals, boosts other antioxidants and vitamins, and is critical in cell metabolism
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