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Yes, unopened Ozempic pens should be refrigerated until you're ready to use them for the first time

Revised: November 2025 Instructions for Use WEGOVY HD INSTRUCTIONS FOR USE SECTION Instructions for Use WEGOVY HD (semaglutide) injection WEGOVY HD comes in the following strength: Before you use your WEGOVY pen for the first time , talk to your healthcare provider or your caregiver about how to prepare and inject WEGOVY correctly

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