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Reported side effects are minimal, but some users in experimental settings have described: Mild fatigue Temporary nausea Headache or dizziness Long-Term Risks The long-term impact of MOTS-c therapy remains unknown, raising concerns about possible risks from prolonged use: Metabolic Overstimulation: chronic AMPK activation may interfere with natural energy signaling

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DOI: 10.46497/ArchRheumatol.2022.9109

and Hawkins P

It is also worth seeking advice if you follow a vegan or vegetarian diet, take medications that may affect B12 absorption, or have a digestive condition that may increase your risk of deficiency