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Given the limited regenerative capacity of neurons, sustained disruption of proteostasis progressively overwhelms cellular quality control systems, leading to synaptic dysfunction, neurodegeneration and irreversible cognitive or motor decline

Moreover, its benefits extend to enhancing physical performance, particularly in individuals with peripheral arterial disease, making it a versatile supplement for those looking to improve both heart health and physical activity levels

Tramadol is considered to have a more favorable side effect profile compared to other opioids

2005, 76 (Suppl 3): 59-62

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