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Search Strategy A comprehensive search of PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed from database inception through the final search date

The compounds bind to entirely different receptors (beta-3 adrenergic vs GLP-1/GIP)

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The scientific consensus is that future metabolic therapies may combine NNMT inhibition with AMPK activation

Desiree Granados Editorial Process Our Editorial Process John DiBella is the co-founder and CEO at The Sanctuary Wellness Institute

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