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No changes were observed in these patients before and after anti-TNF treatment in the plasma GLP-1-response to an oral glucose challenge (101)

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Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline at 48 weeks a figure that, whilst encouraging, should be interpreted with caution as cross-trial comparisons with approved agents are not methodologically robust in the absence of head-to-head data