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Hair tests Can show drug use over a longer period, sometimes up to 90 days, by analyzing hair strands

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Gene silencing by small interfering (siRNA) and short hairpin RNAs (shRNA) Transient and stable gene silencing by siRNA and shRNA, respectively, was performed as previously described 11

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The paper reinforces a familiar but important message: - abnormal tests do not always equal disease - more treatment is not always better care As with many areas of medicine, the challenge is shifting from detecting more to diagnosing better, and from routine treatment to shared, evidenceinformed decisionmaking