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About this article Cite this article Pourabhari Langroudi, A., Chen, A.L., Basran, S

The GI profile (chiefly nausea and vomiting) was slightly more pronounced in the combination group, but most events were transient and of mild-to-moderate severity, leading to discontinuation rates comparable with the single-agent arm [26]

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Heavier individuals also tend to tolerate escalation steps more smoothly because the per-kilogram exposure at each dose level is lower

PMID: 16412534

Severe abdominal pain that radiates to the back and does not stop deserves urgent attention, because pancreatitis is a labeled risk that requires prompt evaluation