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Central Nervous System Agents in Medicinal Chemistry, 23 (2), 137143

The glucagon receptor activation adds additional metabolic effects that create unique safety considerations

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Moving too quickly to high doses wastes product if you respond well to lower amounts, and offers no additional safety buffer if issues arise

Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes, the studys authors wrote