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A Western diet (WD) reduces SCFA levels, potentially impairing neuroprotection, insulin signalling, and intestinal barrier function, and promoting endotoxin-producing bacterial translocation, leading to inflammation and reduced insulin sensitivity [106]
Both significantly improved after 6 weeks
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VPA, a pan-HDACi, has been tested alone or with agents such as ATRA and 5-azacitidine in AML (NCT00995332 and NCT00079378)
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