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Tirzepatide Known by the brand names Mounjaro and Zepbound , tirzepatide is FDA-approved for type 2 diabetes and used off-label for weight loss
It has been reported that these three compounds can enhance the contents of GSH and the activities of GSH-dependent antioxidant enzymes (GPX and GST) and reduce lipid peroxidation and cardiac damage mediated by DOX or isoproterenol (ISO) in the myocardium of rats, respectively [121, 129, 130]
Then its transported to other locations in the cell and even throughout the body
The gradient of the mobile phase was initiated with 100% A, decreased to 0% at 5 min, and remained at 100% A from 7 to 10 min
In line with the well-documented incompatibility between animal experiments and human trials (209, 307, 308), current evidence from systematic reviews identified significant limitations in preclinical animal research, encompassing both the quality of publications and translational value (209, 210)
The hypothalamus, interscapular BAT and trunk blood were collected for subsequent analyses
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