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The post also contrasts onset: metformin gradual over weeks to months, GLP-1 effects appearing within days to weeks
Payers expect specificity
Startups built around elegant but intermediate mechanisms intracellular signaling modulators, phosphatase inhibitors, lipid-handling pathways face a harsher reality
If you have a history of these conditions, GLP-1 medications aren't appropriate, and a responsible provider will identify this during the assessment