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The impact on weight accumulates while the drug is titrated to a maintenance dose, occurring every four weeks in these studies

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If physician-approved, using a reputable pharmacy and following strict storage and handling protocols is essential

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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

They are also known for promoting weight loss, but are they safe for people with heart disease