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The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%)

It is also used with caution in breastfeeding women and children & adolescents (aged below 18 years)

Pharmacological Reviews, 1998

Both drug classes exert pleiotropic effects on metabolic factors, such as obesity and hypertension

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239,240 In summary, GLP-1 lowers blood glucose levels and inhibits glucagon secretion through direct action on -cells, promotion of insulin secretion, and regulation of gastrointestinal activity