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Perspectives in weight control in diabetesSGLT2 inhibitors and GLP-1-glucagon dual agonism

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Particularly in patients who, due to mast cell activation syndrome (MCAS) or food intolerances, only eat limited amounts of food, it is crucial to ensure a sufficient intake of protein and, above all, essential amino acids

REDEFINE Trial Headlines Trial REDEFINE 1 Phase 3 Duration 68 weeks Population (N) 3,417 adults with obesity or overweight + 1 comorbidity, without T2D Key Result 20.4% mean weight change vs 3.0% placebo (treatment-policy)

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The observed prevalence of deficiency (66% of screened patients) aligns with prior reports in pediatric HD populations, reflecting both dialysis-related losses and reduced endogenous synthesis [4, 7]