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It is known that amyloid precursor protein (APP) implicated in development of Alzheimer's disease (AD) can convert Cu (II) into Cu (I) potentially increasing oxidative damage [19]

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[DOI] [PubMed] [Google Scholar] 10.Franzosa E.A., Sirota-Madi A., Avila-Pacheco J., Fornelos N., Haiser H.J., Reinker S., Vatanen T., Hall A.B., Mallick H., McIver L.J., et al

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Curcumin also increases the activity of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activity [29, 30]