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SURMOUNT-5: Tirzepatide vs Semaglutide for Obesity

Malaguarnera, M., et al., L-Carnitine treatment reduces the severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial

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The compound did not impact food intake, suggesting it works through metabolic enhancement rather than appetite suppression

The foundational characterisation comes from Raun et al., 1998, who described ipamorelin as "the first selective growth hormone secretagogue." In the taxonomy of research peptides, ipamorelin therefore sits between the older, less selective compounds such as GHRP-2 and GHRP-6 on one side and the GHRH analogues such as CJC-1295 or tesamorelin on the other