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Additionally, compared to the tumors of mice without drug treatment and those treated with Ru(II)-OH (64.4%) and NP2 (73.6%), the tumors of mice treated with NP4 (81.2%) exhibited a higher proportion of mature DCs (CD80 + CD86 + ) (Supplementary Fig

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Transglutaminase 2 (Tgm2) covalently cross-links IB, further promoting NF-B nuclear translocation and enhancing the expression of phosphorylated p53 and p21