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hUC-MSCs improved ovarian function in CTX-induced POI mice by activating the nuclear-related factor-2 (Nrf-2) antioxidant pathway, enhancing iron metabolism (Nrf-2/ ferritin heavy chain 1(FTH1)), and promoting the antioxidant response (Nrf-2/ glutathione peroxidase 4 (GPX4)), thereby inhibiting ferroptosis [116]

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