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Berberine may also slow gastric emptying through its own mechanisms, which could theoretically amplify tirzepatide's gastrointestinal side effects such as nausea or constipation

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The semaglutide cohort ( n = 1470) compared with the naltrexone/topiramate cohort ( n = 1430) was older, included more women, had a higher prevalence of severe obesity and obesity-associated comorbidities including T2DM and lower prevalence of adverse socioeconomic determinants of health, problems with lifestyle, and substance use disorders