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Abi Zeid Daou et al

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Key takeaways Wegovy is a glucagon-like peptide-1 (GLP-1) agonist available in a weekly injection or daily tablet

The drugs achieve these benefits by mimicking GLP-1s effects: They stimulate insulin production by binding to beta-cells in the pancreas

The Medicare GLP-1 Bridge launches July 2026 at a $50/mo copay for eligible Part D beneficiaries

Avoid microbiome disruptors Certain dietary and lifestyle factors actively harm the bacteria you are trying to establish: Artificial sweeteners (sucralose and saccharin have been shown to negatively affect gut bacteria composition) Excessive alcohol (disrupts gut barrier integrity and kills beneficial bacteria) Highly processed foods (low in fiber, high in additives that harm microbial diversity) Unnecessary antibiotics (the single biggest destroyer of probiotic colonization) Chronic stress (documented effects on gut microbiome composition through the gut-brain axis) People who are working to optimize their metabolic health, whether through dietary modifications alongside GLP-1 medications or through natural approaches, should prioritize removing these disruptors alongside adding beneficial interventions