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This is significant for men who may have prediabetic tendencies or insulin resistance, as many GH-based therapies can temporarily worsen glucose control

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Table 4 Multivariable linear regression analysis for changes in body weight 12 months after GLP-1 receptor agonist initiation

Semaglutide clears the body relatively quickly (half-life ~7 days), but the longer window allows time for your metabolism and hormones to stabilize before pregnancy begins