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The review also documented GSHs role in regenerating vitamin E following detoxification of lipid peroxyl radicals, its involvement in the glyoxalase systems detoxification of dicarbonyl stress induced by methylglyoxal and glyoxal, and its regulation of redox signalling through reversible S-glutathionylation of critical protein cysteine residues

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19 However, tumor cells also utilize GST to form a GSHX complex between antitumor drugs and GSH, proceeding to excrete the complex out of the cell by Pgp and MRP