Even at moderate doses , retatrutide outperformed existing incretin mimetics, with 8 mg weekly doses yielding reductions exceeding 20%
Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue
References: EMC SmPC Ozempic (semaglutide)
UK private prescriptions for both Wegovy and Mounjaro became available shortly after MHRA approval, well before NICE assessed them for NHS use
GLP-1 as a target for therapeutic intervention
Most commonly, this means insulin through multiple daily injections or an insulin pump, though some providers use metformin as an adjunct since its generally considered safe in pregnancy
