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Preconditioning protocols may further confer protection by raising the threshold for mPTP opening, effectively shifting the safe return point and expanding the intervention window (103, 104)
doi: 10.3760/cma.j.cn121430-20201018-00676 [DOI] [PubMed] [Google Scholar] 186.Latourte A, Pascart T, Flipo RM, et al
M.EichenbergerR
Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
This bone loss does not respond to calcium supplementation alone and is not fully explained by vitamin D deficiency
It is central
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