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2EH), while triagonist therapy had no effects on glucose handling, but improved insulin sensitivity and reduced basal glucose levels (Fig

Patients whose index event occurred 20 years or more ago are excluded

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This triple mechanism distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

The Incretin Effect and Active GLP-1 Research indicates that active GLP-1 has many physiological effects on the body such as the incretin effect

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